IRRADIATION AND ADRENAL STEROIDOGENESIS: INFLUENCE OF IRRADIATION OF ISOLATED ACTH-STIMULATED CALF ADRENALS ON THEIR CORTICAL OUTPUT1

1 January 1955

journal article
research article
Published by The Endocrine Society in Endocrinology

Vol. 56 (1) , 30-36
https://doi.org/10.1210/endo-56-1-30

Abstract

Exposure of the isolated, ACTH-stimulated calf adrenal to moderate doses of gamma radiation (Co60) during perfusion resulted in a significantly decreased secretion of hydrocortisone, corticosterone, and unidentified Porter-Silber chromogens. Although the cortex of irradiated animals does not exhibit marked morphological alterations, the present studies suggest that from a functional point of view, the adrenal cortex may be considered a radioresponsive tissue.

Keywords

ACTH/EFFECTS
ADRENAL CORTEX/HORMONES
COBALT/RADIOACTIVE
CORTISONE/PHYSIOLOGY
RADIATIONS/EFFECTS

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