Threshold and Pattern of Electroshock Seizures in Ataxic Manganese-Deficient Rats.

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Abstract
Electroshock convulsions were produced in ataxic, Mn-deficient rats at 80 days of age. The threshold for minimal seizures was significantly lower in the 10 Mn-deficient animals than in the 17 control rats. During a maximal seizure, duration of the tonic flexor phase was markedly shorter in the deficient than in the control rats; duration of the other phases and of postictal depression were similar in both groups. The data are interpreted to mean that brain excitability and convulsability are increased in ataxic Mn-deficient rats; these data may indicate that the brain is involved in the ataxic syndrome characteristic of offspring of Mn-deficient animals.