Endocrine Factors in Senile Osteoporosis

Publisher Website
Google Scholar
Abstract
Serum 1,25-dihydroxyvitamin D[1,25(OH)2D], parathyroid hormone (PTH), calcitonin (CT), Ca, inorganic P and alkaline phosphatase (Al-Pase) levels were determined in 24 patients with senile or postmenopausal osteoporosis, which was diagnosed by lateral X-ray film of lumbar vertebrae and divided into 3 stages, porosis score I, II and III according to its severity. Serum Ca in osteoporotic groups with porosis score II or III was within normal limits but significantly increased compared to that of the age-matched normal group. There was no significant difference in serum inorganic P and serum Al-Pase levels between osteoporotic groups and the age-matched normal group. Serum 1,25(OH)2D level determined by radioreceptor assay was significantly decreased in the osteoporotic group with porosis score III compared to that of the normal group. Serum PTH was on a supernormal or higher than normal level in all osteoporotic groups, while serum CT was within normal limits in those osteoporotic groups. There was no significant correlation among serum 1,25(OH)2D, PTH and CT or between any of these Ca-regulating hormones and serum Ca, inorganic P and Al-Pase, either in osteoporotic groups or in normal groups. Evidently a decrease in serum 1,25(OH)2D is not the only factor for the pathogenesis of senile osteoporosis. Some abnormality in the receptors of the target organs to 1,25(OH)2D3 or some other factor than 1,25(OH)2D3 might be playing a role for an increase of serum PTH level, leading to an increase of bone resorption.

This publication has 0 references indexed in Scilit: