Partition Coefficients for Sevoflurane in Human Blood, Saline, and Olive Oil
- 1 July 1987
- journal article
- research article
- Published by Wolters Kluwer Health in Anesthesia & Analgesia
- Vol. 66 (7) , 654???656-656
- https://doi.org/10.1213/00000539-198707000-00013
Abstract
The purpose of this study was to determine partition coefficients for a new rapid-acting inhaled anesthetic, sevoflurane. Blood samples were taken from 19 ASA physical status I-III patients ranging in age from 21 to 77 yr who were scheduled for elective surgery. At 37°C, we found a blood/gas partition coefficient of 0.686 ± 0.047 (mean ± SD), a saline/gas partition coefficient of 0.370 ± 0.016; and an oil/gas partition coefficient of 47.2 ± 2.7. These values are consistent with the clinical observation that sevoflurane is a potent inhaled anesthetic that produces a rapid induction of and recovery from anesthesia.This publication has 1 reference indexed in Scilit:
- Age and Solubility of Volatile Anesthetics in BloodAnesthesiology, 1984