Response of Bone Sodium to Acute Changes in Serum Sodium: Effect of Age

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Abstract
Rats of varying age were subjected to acute hypernatremia (intraperitoneal hypertonic saline) or acute hyponatremia (intraperitoneal glucose-water), and samples of cortical bone taken for analysis. Over a range in serum Na values of 66 to 246 meq/1 bone Na content varied linearly with serum Na; however the changes were much more pronounced in the younger animals. Calculated Na "space" ([DELTA] bone Na/[DELTA] serum Na) averaged 91% of bone water content. Observed changes in bone Na content could be ascribed entirely to that portion within the "fluid phase" of bone; there was no evidence of a change in "crystal phase" Na.

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