Complete inhibition of the expression of an idiotype by a mechanism of B-cell dominance.
Open Access
- 1 December 1977
- journal article
- research article
- Published by Rockefeller University Press in The Journal of Experimental Medicine
- Vol. 146 (6) , 1574-1584
- https://doi.org/10.1084/jem.146.6.1574
Abstract
Mice of the C.AL-20 strain, which express genes controlling CH regions of the AL/N strain on a BALB/c background, normally synthesize antibodies to the p-azophenylarsonate group (anti-Ar antibodies) with an idiotype characteristic of the A strain. The synthesis of the idiotype, as quantitated by a sensitive assay, can be completely inhibited by the transfer of leukocytes from BALB/c mice producing anti-Ar antibodies, which lack the idiotype. A number of control experiments show that the inhibition is not attributable to suppressor T [thymus-derived] cells and that the synergistic action of such cells is not required. The results indicate that B[bone marrow-derived]-cell dominance, mediated by secondary cells, can completely prevent the expression of unprimed cells with receptors of the same specificity. It is uncertain whether this effect is due entirely to selective capture of antigen by the secondary cells, or whether some type of active suppression by B cells is involved.This publication has 36 references indexed in Scilit:
- Presence on idiotype-specific suppressor T cells of receptors that interact with molecules bearing the idiotype.The Journal of Experimental Medicine, 1977
- Frequency of occurrence of idiotypes associated with anti-p-azophenylarsonate antibodies arising in mice immunologically suppressed with respect to a cross-reactive idiotype.The Journal of Experimental Medicine, 1977
- Relative combining affinities of anti-p-azophenylarsonate antibodies bearing a cross-reactive idiotypeImmunochemistry, 1976
- Production of Large Amounts of Antibodies in Individual MiceThe Journal of Immunology, 1976
- THE MECHANISM OF ANTIGENIC STIMULATION OF PRIMARY AND SECONDARY CLONAL PRECURSOR CELLSThe Journal of Experimental Medicine, 1972
- QUANTITATIVE INVESTIGATIONS OF IDIOTYPIC ANTIBODIESThe Journal of Experimental Medicine, 1972
- Variation in the primary structure of antibodies during the course of immunizationBiochemistry, 1971
- Variations in Affinities of Antibodies during the Immune Response*Biochemistry, 1964
- I131-Labelled Antigen Precipitation as a Measure of Quantity and Quality of AntibodyThe Journal of Infectious Diseases, 1953
- A study of avidity based on rabbit skin responses to diphtheria toxin-antitoxin mixtures.1951