Comparative Effects of Oxygen and of Pyrethrum Synergists on the Action of Certain Insecticides1

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Abstract
The pyrethrum synergists piperonyl butoxide, sulfoxide, and SKF 525 A (2-diethylaminoethyl 2,2-diphenylpentanoate) were found to give some protection to Sitophilus granarius (L.) against the toxic effects of hydrogen cyanide. This protection was most pronounced with SKF 525 A. These compounds, which are believed to exert their synergistic effect by depressing oxidative metabolism, may protect the insects from cyanide poisoning by a similar process. Studies on the effect of oxygen on insects poisoned with different compounds showed that oxygen enhanced the toxic effects of both parathion and para-oxon but it did not affect the toxicity of pyrethrum. In insects treated with allethrin an increase in the oxygen tension had no significant effect but anoxic conditions caused an increase in mortality.

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