The determination of fluocinolone acetonide in formulated products

Abstract
A chromatographic procedure for the determination of fluocinolone acetonide is described. The method employs a hexane: dioxan: water partition system supported on Celite. The progress of the chromatogram is followed by measurement of the ultraviolet absorption of eluate fractions at 238 mμ. The application of the method to the determination of fluocinolone acetonide in cream, ointment and lotion formulations is described.

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