Structure of the gangrene α-toxin: the beauty in the beast
- 1 August 1998
- journal article
- Published by Springer Nature in Nature Structural & Molecular Biology
- Vol. 5 (8) , 659-662
- https://doi.org/10.1038/1351
Abstract
The crystal and molecular structure of the Clostridium perfringens alpha-toxin crowns over a century-long research into the mechanisms of pathogenesis of gas gangrene. The structure reveals a two-domain enzyme, with a catalytic all-helical N-terminal domain, and a C-terminal domain similar in its jelly-roll topology to those found in pancreatic lipase and lipoxygenases.Keywords
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