The Role of Small Intestine and Kidney in Bromosulphthalein Conjugation

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Abstract
The roles of the kidney [guinea pig] and the small intestine in the conjugation of bromosulphthalein were compared with that of the liver. Studies with homogenates indicated that the liver has a higher bromosulphthalein-glutathione-conjugating activity than the intestine and kidney. The reduced glutathione content of the liver is greater than that of the small intestine and kidneys, which contain comparable amounts. Experiments in vitro with tissue slices confirmed that the 3 organs are able to extract significant amounts of bromosulphthalein. In CCl4-induced hepatic necrosis the uptake and conjugation of the dye by the liver were reduced but were increased in the kidney and unchanged in the small intestine. After an i.v. injection of bromosulphthalein, the percentages conjugated in the liver, kidney and gut were similar.

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