Olivanic acids and related compounds: total synthesis of (±)-PS-5 and (±)-6-epi PS-5
- 1 January 1980
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications
- No. 22,p. 1084-1085
- https://doi.org/10.1039/c39800001084
Abstract
The trans- and cis-substituted β-lactam isomers of p-nitrobenzyl 3-(2-acetamidoethylthio)-6-ethyl-7-oxo-1-azabicyclo[3.2.0]heptane-2-carboxylate can be oxidised with iodobenzene dichloride–pyridine under anhydrous conditions to give the 3,4-unsaturated esters, which after isomerisation and deprotection afford the sodium salts of (±)-PS-5 and (±)-6-epi PS-5.Keywords
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