Effect of a Surfactant on Absorption of AM Antibiotic from Non-Aqueous Parenteral Suspensions

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Abstract
Attempts to modify the absorption of a monocyclic beta-lactam antibiotic from an oily suspension formulation were made by incorporation of the non-ionic surfactant sorbitan trioleate. Time to serum peak concentration was increased with increased level of surfactant and there anpeared to be more efficient clearance of the antibiotic from the depot with increase in level of surfactant in the formulation. The second effect may be explained in terms of the physical characteristics of the formulations whereas the alteration in time to serum peak concentrations may be due to an effect of the surfactant on transport of drug throuah tissue.