Melanoma in an Albino

29 November 1963

journal article
research article
Published by American Medical Association (AMA) in JAMA

Vol. 186 (9) , 839-841
https://doi.org/10.1001/jama.1963.03710090039008

Abstract

The diagnosis of a malignant melanoma in a pure albino patient was clearly established by electronmicroscopic demonstration of premelanosomes and melanosome structures in the amelanotic cancer cells. It appears that the melanocyte is necessary for the development of this cancer, but the metabolic pathway for melanin production is not. The latter is a guide to the chemotherapeutic control of melanomas. Removal of nevi or birthmarks in albinos may prevent the development of this cutaneous malignancy.

Keywords

ALBINISM
MECHLORETHAMINE
MELANIN
MELANOMA
MICROSCOPY, ELECTRON
NEOPLASM METASTASIS
PATHOLOGY
SKIN NEOPLASMS
THIO-TEPA

This publication has 1 reference indexed in Scilit:

SUBCELLULAR LOCALIZATION OF MELANIN BIOSYNTHESTS
Annals of the New York Academy of Sciences, 1963