Intestinal epithelial responses to enteric pathogens: effects on the tight junction barrier, ion transport, and inflammation
Top Cited Papers
Open Access
- 1 March 2003
- Vol. 52 (3) , 439-451
- https://doi.org/10.1136/gut.52.3.439
Abstract
The effects of pathogenic organisms on host intestinal epithelial cells are vast. Innumerable signalling pathways are triggered leading ultimately to drastic changes in physiological functions. Here, the ways in which enteric bacterial pathogens utilise and impact on the three major physiological functions of the intestinal epithelium are discussed: alterations in the structure and function of the tight junction barrier, induction of fluid and electrolyte secretion, and activation of the inflammatory cascade. This field of investigation, which was virtually non-existent a decade ago, has now exploded, thus rapidly expanding our understanding of bacterial pathogenesis. Through increased delineation of the ways in which microbes alter host physiology, we simultaneous gain insight into the normal regulatory mechanisms of the intestinal epithelium.Keywords
This publication has 141 references indexed in Scilit:
- The Salmonella typhimurium Flagellar Basal Body Protein FliE Is Required for Flagellin Production and to Induce a Proinflammatory Response in Epithelial CellsPublished by Elsevier ,2002
- Cl − Secretion in Colonic Epithelial Cells Induced by the Vibrio parahaemolyticus Hemolytic Toxin Related to Thermostable Direct HemolysinInfection and Immunity, 2000
- Regulation of NF-κB RelA Phosphorylation and Transcriptional Activity by p21 and Protein Kinase Cζ in Primary Endothelial CellsJournal of Biological Chemistry, 1999
- Reversion of Ras- and Phosphatidylcholine-hydrolyzing Phospholipase C-mediated Transformation of NIH 3T3 Cells by a Dominant Interfering Mutant of Protein Kinase C λ Is Accompanied by the Loss of Constitutive Nuclear Mitogen-activated Protein Kinase/Extracellular Signal-regulated Kinase ActivityJournal of Biological Chemistry, 1997
- Cloning and Quantification of Galanin-1 Receptor Expression by Mucosal Cells Lining the Human Gastrointestinal TractBiochemical and Biophysical Research Communications, 1996
- Occludin: a novel integral membrane protein localizing at tight junctions.The Journal of cell biology, 1993
- 5'-adenosine monophosphate is the neutrophil-derived paracrine factor that elicits chloride secretion from T84 intestinal epithelial cell monolayers.Journal of Clinical Investigation, 1993
- Intestinal Electrolyte Transport and Diarrheal DiseaseNew England Journal of Medicine, 1989
- Clostridium difficile toxin B induces reorganization of actin, vinculin, and talin in cultured cellsExperimental Cell Research, 1988
- Ca ionophore-stimulated ion secretion in rabbit ileal mucosa: Relation to actions of cyclic 3′,5′-AMP and carbamylcholineThe Journal of Membrane Biology, 1977