THE BILIARY EXCRETION OF SULFOBROMOPHTHALEIN SODIUM (BSP) IN THE RAT AS A CONJUGATE OF GLYCINE AND GLUTAMIC ACID *†
Open Access
- 1 August 1959
- journal article
- research article
- Published by American Society for Clinical Investigation in Journal of Clinical Investigation
- Vol. 38 (8) , 1426-1433
- https://doi.org/10.1172/jci103919
Abstract
An analysis of sulfobromophthalein sodium (BSP) compounds appearing in rat bile after intravenous administration reveals 4 distinct bands by filter paper chromatography, one of which migrated with the same Rf as standard BSP. The major band, designated BSP-A, accounted for 50 to 80% of the excreted BSP when graded doses of this dye were administered. Hydrolysis of BSP-A yielded BSP and 2 ninhydrin spots which were identified as glycine and glutamic acid. No evidence of a glucuronic acid conjugate was found.Keywords
This publication has 10 references indexed in Scilit:
- Biliary Excretion by the Rat of Bromsulfalein as a Conjugate of Glycine and Glutamic AcidScience, 1959
- Metabolism of Sulfobromophthalein Sodium (BSP) in the RatAmerican Journal of Physiology-Legacy Content, 1958
- Bilirubin Glucuronide Formation in vitro ; Demonstration of a Defect in Gilbert's DiseaseScience, 1957
- The mechanisms of bromsulfalein removal from the blood.1956
- THE DISTRIBUTION AND EXCRETION OF S35-LABELED SULFO-BROMOPHTHALEIN-SODIUM ADMINISTERED TO DOGS BY CONTINUOUS INFUSION 1Journal of Clinical Investigation, 1955
- INVESTIGATION OF GLUCURONIC ACID METABOLISM IN HUMAN SUBJECTS 12Journal of Clinical Investigation, 1951
- The separation of N-2:4-dinitrophenyl amino-acids on paper chromatogramsBiochemical Journal, 1951
- HEPATIC UPTAKE AND BILIARY EXCRETION OF BROMSULPHTHALEIN IN THE DOGAmerican Journal of Physiology-Legacy Content, 1950
- THE REMOVAL OF BROMSULPHTHALEIN FROM BLOOD PLASMA BY THE LIVER OF THE RAT1949
- STUDIES WITH BROMSULFALEIN .1. FACTORS ALTERING ITS DISAPPEARANCE FROM THE BLOOD AFTER A SINGLE INTRAVENOUS INJECTION1949