Gastric Mucosa in Female Patients with Fundic Glandular Polyps

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Abstract
O evaluate the characteristics of the gastric mucosa in women with fundic glandular polyps, we examined gastric acid secretion, fasting serum levels of pepsinogen I and gastrin, and gastric histology in 11 female patients with fundic polyps, and compared the results with 30 female controls without endoscopic abnormalities and 50 female patients with gastric foveolar hyperplastic polyps. To significant difference was found in gastric acid secreton and fasting serum levels of pepsinogen I and gastrin between the patients with fundic glandular polyps and the control subjects. Histological examination showed that trophic gastritis was generally not found in the patients with fundic glandular polyps. In contrast, gastric acid secretion and fasting serum levels of pepsinogen I were significantly lower and serum gastrim levels were significantly higher in the patients with foveolar hyperplastic polyps than in the other two groups. Also, patients with oveolar hyperplastic polyps had a higher prevalence and furhter advanced atrophic gastritis in the fundus than did the other two groups. Our investigations demonstrated hat fundic glandular polyps arise from gastric mucosa without atrophic gastritis, whereas foveolar hyperplastic polyps develp from mucosa affected by atrophic gastriis, especially type A gastritis.

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