Clinical ocular toxoplasmosis in neonatal kittens

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Abstract
Objective: To describe ocular findings in kittens with congenital or early neonatal infection byToxoplasma gondiiand to determine if there are detectable differences in disease caused by three strains.Animals studied: Six adult female cats and the offspring from seven litters.Methods: Four kittens from uninfected specific pathogen‐free (SPF) queens and 21 kittens from SPF queens inoculated at various times late in gestation with Mozart, Maggie, or ME‐49 strain ofT. gondiiwere used. Ocular examinations were performed on queens prior to and after delivery, and on kittens weekly to bi‐weekly for up to 27 weeks. Whole blood for serology was collected from all kittens at 5½ to 8 weeks of age and again at 12 weeks of age or later.Results: No kittens from noninfected queens developed ocular lesions or antibody toT. gondii. Three of the 24 kittens from infected queens died or were euthanized early in the study. Chorioretinitis was detected in 15 of 21 living kittens from infected queens. Two developed concurrent anterior uveitis that resolved within 1 week. Posterior segment lesions varied ophthalmoscopically between strains. Of 21 kittens fromT. gondii‐infected queens, six developed positive antibody titers toT. gondiiduring the study. All seropositive kittens were born to queens infected with Mozart strain ofT. gondii.Conclusion: Results of this study suggest that ocular toxoplasmosis can occur without other evidence of clinical illness in kittens infectedin uteroor in the neonatal period, and thatT. gondiistrains may have varying degrees of ocular pathogenicity in cats.

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