Increased plasma concentrations of soluble tumor necrosis factor receptors in sepsis syndrome

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Abstract
Tumor necrosis factor (TNF) is an important mediator in the complex pathophysiology of sepsis syndrome. Although a positive correlation with mortality rate has been demonstrated, TNF has not been found consistently in sepsis. Since prolonged increases in soluble TNF receptor concentrations were demonstrated after endotoxin and TNF administration, we investigated whether the measurement of TNF receptor concentrations could provide a better indicator of disease than plasma TNF and interleukin (IL)-6 concentrations. Prospective analysis. General intensive care unit (ICU) of a university hospital. Twenty-six patients with sepsis syndrome and proven bacteremia. Plasma peak concentrations of the soluble 55-kilodalton molecular weight TNF receptor were significantly higher (p Conclusions In the population studied, plasma-soluble TNF receptor concentrations correlated with outcome as well as with plasma creatinine concentrations. The data presented suggest that increased plasma-soluble TNF receptor concentrations in patients with sepsis syndrome are merely the result of renal failure complicating sepsis, and are similarly correlated with mortality rate. (Crit Care Med 1994; 22:803–809)

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