Vibrio cholerae tolC Is Required for Bile Resistance and Colonization
Open Access
- 1 July 2001
- journal article
- Published by American Society for Microbiology in Infection and Immunity
- Vol. 69 (7) , 4681-4685
- https://doi.org/10.1128/iai.69.7.4681-4685.2001
Abstract
TolC and its homologues are outer membrane proteins that are essential for the transport of many molecules across the cell envelope. In this study we characterized the gene encoding Vibrio cholerae TolC. V. cholerae tolC mutants failed to secrete the RTX cytotoxin, were hypersensitive to antimicrobial agents, and were deficient in intestinal colonization.Keywords
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