There have been conflicting reports about the existence of non-shivering thermogenesis in the newborn calf of domestic cattle. The present experiments show that intravenous infusion of noradrenaline (1 μg·kg––1·min––1) causes a large increase in the temperature of perirenal adipose tissue, and a smaller increase in mixed-venous-blood temperature of calves. The animal’s total oxygen consumption increases and respiratory quotient decreases. On the first day of life the noradrenaline produces a large temperature difference between adipose tissue and blood, and a large increase in total oxygen consumption. This response disappears with age, with great variation between individual animals.