CIRCADIAN RHYTHMS OF PRESUMPTIVE STEM CELLS IN THREE DIFFERENT EPITHELIA OF THE MOUSE

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Abstract
Variation in percentage of labeled cells (LI), mitoses (MI) and apoptosis (AI: i.e., shrinkage necrosis) were studied throughout a 24-h period (40 min after labeling with 3H-TdR) for tongue epithelium, epidermis and intestinal epithelium in the mouse. A room with reversed light cycle was used to obtain data for half of the 24-h period. All 3 tissues showed marked variations in LI with peak values between 24 and 3 h. In the intestine a maximum value for MI was observed 3-6 h after that for LI and with a maximum value for AI slightly later. In all 3 epithelia the circadian rhythm was most striking in cells at positions which can be correlated with presumptive stem cell activity, e.g., in the crypts the labeling and mitotic peaks reflecting a circadian rhythm were most clearly distinguishable at the basal part of the crypts. These observations are discussed in relation to the validity of various proliferative models.

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