The measurement of the components of the plasminogen–plasmin system in biological fluids

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Abstract
A method of fibrin lysis with an objective end point, and suitable for the measurement of free plasmin activity in biological fluids is presented. The accuracy of the method over the range 1-28 Christensen units/ml is [plus or minus]. 10%. Streptokinase converts a high proportion of plasminogen into plasmin at low plasminogen concentrations, but converts only a low proportion at high plasminogen concentrations. The important role played by non-specific inhibition of plasmin as against specific inhibition of plasmin in biological fluids was emphasized, and the possibility that such enzyme may be physiologically active was suggested.