Comparison of the pupillary, refractive, and hypotensive effects of Ocusert-40 and pilocarpine eyedrops in the treatment of chronic simple glaucoma.

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Abstract
Patients (12) with chronic simple glaucoma were treated for 1 wk with Ocusert-40 and the effects on the pupil, intraocular pressure and refraction were measured. A comparison was made with the effects of pilocarpine eyedrop therapy in 8 of these patients. Both forms of pilocarpine treatment gave satisfactory control of intraocular pressure and both constricted the pupil to a similar degree shortly after initiation of treatment. During the wk on Ocusert-40 the pupils redilated, so that 54% of the initial miosis remained after 7 days'' wear. There was considerable variability in pupillary sensitivity to Ocusert-40 within and between eyes, and this may have been partly due to variable pilocarpine release rates. Only minor decreases in visual acuity and refraction resulted from pilocarpine in either form. Of the 12 patients, 7 rejected Ocusert-40 because of discomfort or inability to retain the device.