Urinary cyclic AMP and vasopressin excretion in rat strains selected for their alcohol intake

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Abstract
Urinary excretion of cyclic(c)AMP and immunoreactive arginine vasopressin (AVP) were investigated after water loading and following ethanol loading in 2 rat strains selected for their voluntary ethanol intake. After ethanol loading ethanol preferring (AA) rats excreted more cAMP but less AVP than water preferring (ANA) rats. The strain difference in cAMP excretion was apparently of renal origin and was not due to vasopressin or parathormone. Differences in the sympathetic nervous activity may be responsible for the difference in cAMP excretion.