Synthetic Studies of Halichondrin B, an Antitumor Polyether Macrolide Isolated from a Marine Sponge. 2. Efficient Synthesis of C16-C26 FragmentsviaConstruction of the D Ring by a Highly Stereocontrolled Iodoetherification
- 1 January 1994
- journal article
- letter
- Published by Georg Thieme Verlag KG in Synlett
- Vol. 1994 (01) , 40-43
- https://doi.org/10.1055/s-1994-22731
Abstract
A stereoselective synthesis of C16-C26 fragments of halichondrin B starting from D-malic acid and methyl (2S)-3-hydroxy-2-methylpropionate using iodoetherification for an efficient construction of the D ring as the key step is described.Keywords
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