Urinary Output and Phosphorus Excretion in Human Subjects During Prolonged Exposures at Low Simulated Altitudes.

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Abstract
Urinary secretion and phosphorus excretion were studied in 5 subjects over 10 hr. exposure periods at simulated altitudes of 8,000 and 10,000 ft. under conditions of standardized food and water intake. No appreciable change in total urinary output from the values at ground level was found at either altitude studied, either in early or late exposures. The most characteristic feature of urinary elimination was the considerable degree of variation from run to run, despite the carefully controlled food and water intake. The total urinary excretion of inorganic P was significantly decreased in all subjects, the decrease becoming apparent early in the exposure period at either 8,000 or 10,000 feet. The rate of excretion increased with increasing exposure time at ground level. The reduced P output at altitude bore no apparent relationship to the urinary output, nor could it be directly correlated with changes in respiratory metabolism or in blood sugar level. These expts. provide evidence to indicate that alterations in the mineral metabolism may occur in the unacclimatized human being at altitudes as low as 8,000 ft.

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