BIPHASIC ENDOTOXIN FEVER IN NEWBORN RABBIT

  • 1 January 1978
    • journal article
    • research article
    • Vol. 51  (4) , 389-392
Abstract
Rabbits aged 6-10 days responded to 20 or 50 .mu.g/kg i.p. or i.v. Escherichia coli endotoxin in with characteristic biphasic fever, whereas 0-3 day old rabbits reacted with monophasic fever which coincided with the first-phase rise of the older group. In the rabbit, the mechanisms responsible for the first-phase and the second-phase febrile temperature rises appear separately in ontogenesis in the 1st week of extrauterine life.