PARATHYROID HYPERPLASIA IN RABBITS PRODUCED BY PARENTERAL PHOSPHATE ADMINISTRATION 1
Open Access
- 1 March 1937
- journal article
- research article
- Published by American Society for Clinical Investigation in Journal of Clinical Investigation
- Vol. 16 (2) , 203-206
- https://doi.org/10.1172/jci100848
Abstract
The average weight of the inferior pair of parathyroid glands of 19 control rabbits was 13 mgm.; the corresponding figure for 19 rabbits which had received injections of parenteral phosphate thrice daily for 1 to 108 days was 20 mgm. The parathyroid glands of the injected animals showed definite histological evidence of hyperplasia. The findings support the hypothesis that phosphate retention is the cause of the parathyroid hyperplasia in cases of chronic renal insufficiency; it will require further studies to show whether the hyperphosphatemia causes the hyperplasia directly, or indirectly by producing a hypocalcemia.This publication has 1 reference indexed in Scilit: