A Single Amino Acid Substitution in the Virus-Encoded Replicase of Tomato Mosaic Tobamovirus Alters Host Specificity

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Abstract
Introduction of a single amino acid substitution (Gln979 to Ile) into the 130- and 180-kDa proteins of tomato mosaic tobamovirus (ToMV) rendered the mutant virtually unable to replicate in tomato cells while it replicated perfectly in tobacco cells. The mechanism of this change in host specificity is discussed.