Discovery of N-(2-hydroxy-2-aryl-cyclohexyl) substituted spiropiperidines as GlyT1 antagonists with improved pharmacological profile

This publication has 16 references indexed in Scilit:

• Glycine transporters: essential regulators of neurotransmission
  Trends in Biochemical Sciences, 2005
• N-Methyl-d-aspartate receptors as a target for improved antipsychotic agents: novel insights and clinical perspectives
  Psychopharmacology, 2005
• The synthesis and SAR of 2-arylsulfanyl-phenyl piperazinyl acetic acids as glyT-1 inhibitors
  Bioorganic & Medicinal Chemistry Letters, 2004
• Discovery and SAR of Org 24598—A Selective Glycine Uptake Inhibitor
  Bioorganic & Medicinal Chemistry Letters, 2001
• Glycine neurotransmitter transporters: an update
  Molecular Membrane Biology, 2001
• Genetic enhancement of learning and memory in mice
  Nature, 1999
• Mice with Reduced NMDA Receptor Expression Display Behaviors Related to Schizophrenia
  Cell, 1999
• Reversal of phencyclidine-induced effects by glycine and glycine transport inhibitors
  Biological Psychiatry, 1999
• Modulation of N -methyl- d -aspartate receptor function by glycine transport
  Proceedings of the National Academy of Sciences, 1998
• A synaptic model of memory: long-term potentiation in the hippocampus
  Nature, 1993