Intracranial Self-Stimulation and Wakefulness: Effect of Manipulating Ambient Brain Catecholamines
- 12 June 1970
- journal article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 168 (3937) , 1370-1372
- https://doi.org/10.1126/science.168.3937.1370
Abstract
Rats were given disulfiram, an inhibitor of norepinephrine biosynthesis, to see if norepinephrine is a transmitter for motivation in electrical stimulation of the brain. Animals given the drug paused in bar pressing, appearing asleep or sedated; if replaced on the bar, they always resumed pressing at normal rates. The decrease in bar pressing may result from a direct or indirect effect of the drug on wakefulness rather than on reward.Keywords
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