Electrophysiological characterization of BmK M1, an α‐like toxin from Buthus martensi Karsch venom
- 19 April 2001
- journal article
- Published by Wiley in FEBS Letters
- Vol. 495 (1-2) , 61-65
- https://doi.org/10.1016/s0014-5793(01)02365-1
Abstract
The present study investigates the electrophysiological actions of BmK M1, an α‐like toxin purified from the venom of the scorpion Buthus martensi Karsch, on voltage‐gated Na+ channels. Using the voltage clamp technique, we assessed the BmK M1 activity on the cardiac Na+ channel (hH1) functionally expressed in Xenopus oocytes. The main actions of the toxin are a concentration‐dependent slowing of the inactivation process and a hyperpolarizing shift of the steady‐state inactivation. This work is the first electrophysiological characterization of BmK M1 on a cloned Na+ channel, demonstrating that this toxin belongs to the class of scorpion α‐toxins. Our results also show that BmK M1 can be considered as a cardiotoxin.Keywords
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