FIBRINOLYTIC ACTIVITY OF HEMOLYTIC STREPTOCOCCI. THE DEVELOPMENT OF RESISTANCE TO FIBRINOLYSIS FOLLOWING ACUTE HEMOLYTIC STREPTOCOCCUS INFECTIONS
Open Access
- 1 January 1934
- journal article
- research article
- Published by American Society for Clinical Investigation in Journal of Clinical Investigation
- Vol. 13 (1) , 47-78
- https://doi.org/10.1172/jci100579
Abstract
Human strains of Streptococcus hemolyticus are capable of dissolving clotted plasma of human blood with great rapidity. This fibrinolytic activity was studied by employing plasma clots from blood of 3 groups of persons: (1) Patients with acute infections known to be due to Strep. hemolyticus; (2) acute infections due to other bacteria, such as pneumococcus pneumonia, typhoid, etc.; and (3) so-called normal individuals, 3-73 yrs. old. Repeated tests with blood obtained before and after recovery from cases in (1) showed development of a specific resistance which prevented fibrinolysis by the streptococci, while none developed in blood of patients belonging to (2). Of 60 so-called normals, the plasma clots of about 70-75% were highly susceptible to fibrinolysis; the remaining 25-30% possessed varying degrees of resistance.This publication has 1 reference indexed in Scilit:
- THE FIBRINOLYTIC ACTIVITY OF HEMOLYTIC STREPTOCOCCIThe Journal of Experimental Medicine, 1933