Crystal structure of the human class II MHC protein HLA-DR1 complexed with an influenza virus peptide
Open Access
- 1 March 1994
- journal article
- research article
- Published by Springer Nature in Nature
- Vol. 368 (6468) , 215-221
- https://doi.org/10.1038/368215a0
Abstract
An influenza virus peptide binds to HLA-DR1 in an extended conformation with a pronounced twist. Thirty-five per cent of the peptide surface is accessible to solvent and potentially available for interaction with the antigen receptor on T cells. Pockets in the peptide-binding site accommodate five of the thirteen side chains of the bound peptide, and explain the peptide specificity of HLA-DR1. Twelve hydrogen bonds between conserved HLA-DR1 residues and the main chain of the peptide provide a universal mode of peptide binding, distinct from the strategy used by class I histocompatibility proteins.Keywords
This publication has 50 references indexed in Scilit:
- The interpretation of protein structures: Estimation of static accessibilityPublished by Elsevier ,2004
- Two-dimensional Nuclear Magnetic Resonance Analysis of a Labeled Peptide Bound to a Class II Major Histocompatibility Complex MoleculeJournal of Molecular Biology, 1993
- Three-dimensional structure of the human class II histocompatibility antigen HLA-DR1Nature, 1993
- Common Ring Motifs in Proteins Involving Asparagine or Glutamine Amide Groups Hydrogen-bonded to Main-chain AtomsJournal of Molecular Biology, 1993
- The Biochemistry and Cell Biology of Antigen Processing and PresentationAnnual Review of Immunology, 1993
- Predominant naturally processed peptides bound to HLA-DR1 are derived from MHC-related molecules and are heterogeneous in sizeNature, 1992
- Identification of self peptides bound to purified HLA-B27Nature, 1991
- The structure of HLA-B27 reveals nonamer self-peptides bound in an extended conformationNature, 1991
- Allele-specific motifs revealed by sequencing of self-peptides eluted from MHC moleculesNature, 1991
- Ribbon models of macromoleculesJournal of Molecular Graphics, 1987