A clustered plasticity model of long-term memory engrams
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- 1 July 2006
- journal article
- review article
- Published by Springer Nature in Nature Reviews Neuroscience
- Vol. 7 (7) , 575-583
- https://doi.org/10.1038/nrn1937
Abstract
Long-term memory and its putative synaptic correlates the late phases of both long-term potentiation and long-term depression require enhanced protein synthesis. On the basis of recent data on translation-dependent synaptic plasticity and on the supralinear effect of activation of nearby synapses on action potential generation, we propose a model for the formation of long-term memory engrams at the single neuron level. In this model, which we call clustered plasticity, local translational enhancement, along with synaptic tagging and capture, facilitates the formation of long-term memory engrams through bidirectional synaptic weight changes among synapses within a dendritic branch.Keywords
This publication has 107 references indexed in Scilit:
- Regulation of Eukaryotic Initiation Factor 4E by Converging Signaling Pathways during Metabotropic Glutamate Receptor-Dependent Long-Term DepressionJournal of Neuroscience, 2006
- Reverse replay of behavioural sequences in hippocampal place cells during the awake stateNature, 2006
- Local Protein Synthesis Mediates a Rapid Increase in Dendritic Elongation Factor 1A after Induction of Late Long-Term PotentiationJournal of Neuroscience, 2005
- β-Adrenergic Receptor Activation Facilitates Induction of a Protein Synthesis-Dependent Late Phase of Long-Term PotentiationJournal of Neuroscience, 2005
- Biochemical mechanisms for translational regulation in synaptic plasticityNature Reviews Neuroscience, 2004
- Brain-Derived Neurotrophic Factor Induces Mammalian Target of Rapamycin-Dependent Local Activation of Translation Machinery and Protein Synthesis in Neuronal DendritesJournal of Neuroscience, 2004
- A Role for ERK MAP Kinase in Physiologic Temporal Integration in Hippocampal Area CA1Learning & Memory, 2003
- Synaptic plasticity and learning and memory: LTP and beyondJournal of Neuroscience Research, 1999
- Dynamics of the Hippocampal Ensemble Code for SpaceScience, 1993
- Anisomycin, an inhibitor of protein synthesis, blocks late phases of LTP phenomena in the hippocampal CA1 region in vitroBrain Research, 1988