Physiologic Role of Sodium-Potassium-Activated Adenosine Triphosphatase in the Transport of Cations across Biologic Membranes

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Abstract
IN the last decade considerable evidence has been accumulated to support the concept that a sodium-potassium-activated adenosine triphosphatase (Na-K-ATPase) is intimately involved in the active transport of electrolytes across biologic membranes. After the original demonstration of enzymatic activity in the peripheral nerve of the crab by Skou1 investigators pointed out the close resemblance of biochemical characteristics and intracellular localization in various animal tissues between such activity and systems of active transport. Although the information thus obtained provides a strong base of indirect evidence for the participation of Na-K-ATPase in membrane transport, there are few studies, aside from those in red . . .
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