Dynamics and Thermodynamics of Dimerization of Parallel G-Quadruplexed DNA Formed from d(TTAGn) (n = 3−5)
- 23 June 2005
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of the American Chemical Society
- Vol. 127 (28) , 9980-9981
- https://doi.org/10.1021/ja050191b
Abstract
Parallel G-quadruplexes formed from oligonucleotide sequences, d(TTAGn), where n = 3-5, have been shown to form a dimer through end-to-end stacking of 3'-terminal G-tetrads. The monomers and dimers of the G-quadruplexes are in dynamic equilibrium with an exchange rate of approximately 1 s-1. A thermodynamic study demonstrated that the dimerization of the G-quadruplexes is largely enthalpic in origin.Keywords
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