Prazosin in the diagnosis and treatment of pheochromocytoma

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Abstract
In a patient with paraganglioma, severe hypertension due to high levels of plasma norepinephrine was easily controlled with prazosin hydrochloride, 6-8 mg/day for 19 days before surgery. A prolonged antihypertensive response to the 1st two 1 mg doses suggested the presence of pheochromocytoma. This experience dramatizes the remarkable effectiveness of prazosin as a postsynaptic .alpha.-adrenergic receptor blocker and invites further trials of the drug for the diagnosis and treatment of pheochromocytoma.