Synthesis of Antimicrobial Agents. II. Synthesis of 1, 8-Naphthyridine Derivatives and Their Activities against Trichomonas vaginalis
Open Access
- 1 January 1979
- journal article
- research article
- Published by Pharmaceutical Society of Japan in YAKUGAKU ZASSHI
- Vol. 99 (2) , 155-164
- https://doi.org/10.1248/yakushi1947.99.2_155
Abstract
In order to find new antimicrobial agents, a number of substituted 1,8-naphthyridine derivatives and related compounds were synthesized. Nitration of nalidixic acid with fuming sulfuric acid and fuming nitric acid gave 1-ethyl-1,4-dihydro-3-nitro-4-oxo-1,8-naphthyridine-7-carboxylic acid. Ethyl 7-substituted amino-1-ethyl-1,4-dihydro-6-nitro-4-oxo-1,8-naphthyridine-3-carboxylate obtained in this work showed nearly the same activity with metronidazole against T. vaginalis.Keywords
This publication has 1 reference indexed in Scilit:
- Synthesis of antimicrobial agents. I. Synthesis and antimicrobial activities of thiazoloquinoline derivatives.CHEMICAL & PHARMACEUTICAL BULLETIN, 1979