Synthesis and Applications of Oligoribonucleotides Containing N4-Methylcytidine
- 1 May 1995
- journal article
- research article
- Published by Taylor & Francis in Nucleosides, Nucleotides and Nucleic Acids
- Vol. 14 (3) , 1129-1132
- https://doi.org/10.1080/15257779508012548
Abstract
The modified nucleoside N 4-methylcytidine was incorporated in place of individual C residues in synthetic TAR and RRE RNA duplexes representing the binding sites for the HIV-1 tat and rev proteins respectively. In no case was cognate protein binding disrupted showing that the exocyclic amino groups of C residues are not sites of protein recognition.Keywords
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