An efficient synthesis of julibrosides related to neosaponin
- 1 January 2001
- journal article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 1
- No. 18,p. 2289-93
- https://doi.org/10.1039/b009955o
Abstract
A practical method is developed for the synthesis of neosaponin cholest-5(6)-en-3β-yl β-D-glucopyranosyl-(1→3)-[α-L-arabinofuranosyl-(1→4)]-α-L-rhamnopyranosyl-(1→2)-β-D-glucopyranoside. This julibroside mimic shows cytotoxic activity towards P388 (mouse leukaemia) with GI50 = 22.5 μg mL−1.Keywords
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