Carbon Dioxide Effects on Myocardial Contractility.

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Abstract
Summary Rat myocardial preparations were stimulated to contract at one per second in an oxygenated Ringer's solution. The effects of 0%, 2% and 5% CO2 on the magnitude of the isometric developed tension were studied during a 3-hour experimental period. It was noted that muscles aerated with a gas mixture containing 2% CO2 revealed not only a constant developed tension but also a small variation in contractile response during the experiments. The detrimental effects of the other percentages of CO2 on the developed tension were not immediately evident.

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