Effects of melatonin and the melatonin receptor agonist S‐20098 on the vigilance states, EEG spectra, and cortical temperature in the rat

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Abstract
Tobler I, Jaggi K, Borbély AA. Effects of melatonin and the melatonin receptor agonist S-20098 on the vigilance states, EEG spectra, and cortical temperature in the rat. J. Pineal Res. 1994: 16: 26–32. Abstract The effects of melatonin (3 mg/kg i.p.) and the melatonin receptor agonist S-20098 (3 mg/kg i.p.) on the vigilance states, electroencephalogram power spectra (0.25–25.0 Hz), and cortical temperature were determined in eight rats in the first 6-hr interval of the 12-hr light period. Compared to the vehicle injection both compounds reduced the power density in non-rapid eye movement sleep in the low frequency range (1–8 Hz) but did not affect the vigilance states and brain temperature. The present findings do not indicate that the stimulation of the melatonin receptor exerts a hypnotic effect at doses that had been shown to affect the circadian rest-activity rhythm.