Tris(trimethylsilyl)silane as a Reagent for the Radical Deoxygenation of Alcohols
- 1 January 1990
- journal article
- letter
- Published by Georg Thieme Verlag KG in Synlett
- Vol. 1990 (11) , 705-706
- https://doi.org/10.1055/s-1990-21219
Abstract
The reaction of Barton and McCombie was improved by the substitution of tributyltin hydride with the new reagent tris(trimethylsilyl)silane for a smooth radical deoxygenation of cholesterol, lanosterol and 1,2:5,6-di-O-isopropylidene-D-glucofuranose, via the corresponding O-phenoxythiocarbonyl derivatives, without toxic tin-containing byproducts in the reaction mixtures.Keywords
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