Fluid and electrolyte balance during acute withdrawal in chronic alcoholic patients

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Abstract
Total body water, extracellular volume, and plasma volume were measured in 30 well-nourished, chronic alcoholics. Plasma and erythrocyte electrolyte concentration and excretion were measured. Isosmotic overhydration with normal concentrations was found on admission to the hospital. With no specific fluid or electrolyte therapy, total body water level decreased to normal 4 days later. Abnormal liver function was found in all patients. Empirical and ubiquitous use of fluids in alcoholics, presumed to be dehydrated, may only exacerbate overhydration.