RNA METABOLISM IN SEMINAL VESICLE AND PROSTATE OF IMMATURE RATS FOLLOWING CASTRATION AND ANDROGEN REPLACEMENT

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Abstract
The incorporation of 3H-cytidine into cytoplasmic but not into nuclear RNA of the ventral prostate decreased 8 hours after castration in 5-week old rats. The radioactivities of nuclear and cytoplasmic RNAs in the seminal vesicle were unchanged at this time. The seminal vesicle responded more markedly than ventral prostate to a single injection of testosterone with increased growth and increased synthesis of RNA and proteins. The incorporation of 14C-proline into protein was increased by testosterone at 12 hours in the seminal vesicle and at 24 hours in the ventral prostate. The specific activity of the protein in the liver decreased significantly 72 hours after castration and increased 48 hours after the administration of testosterone.

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