Penetration of 14C Hydrocortisone Through Normal Skin
- 1 June 1965
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of Dermatology
- Vol. 91 (6) , 661-666
- https://doi.org/10.1001/archderm.1965.01600120093023
Abstract
Between 0.2 and 1.0 per cent of hydrocortisone, applied to normal skin appears in the urine over a period of ten days. Stripping the skin doubles this amount and significantly alters the absorption rate curve. An occlusive dressing increases absorption ten-fold but does not basically alter the absorption rate curve. Evidence is presented suggesting that both the stratum corneum and the Malpighian/basal layers serve as skin barriers.Keywords
This publication has 3 references indexed in Scilit:
- Percutaneous Absorption of C14-Labeled Triamcinolone AcetonideArchives of Dermatology, 1963
- Existence of Reservoir in the Stratum CorneumArchives of Dermatology, 1963
- Percutaneous Absorption of Hydrocortisone-4-C* in Two Human Subjects*Journal of Investigative Dermatology, 1955