Effect of Prior Treatment with Thioglycolate on the Incubation Period of Intraperitoneally Injected Scrapie

Abstract
Injection of mice with thioglycolate 5 days prior to intraperitoneal injection of scrapie brain homogenate led to a statistically significant increase in scrapie incubation periods. This was seen with different scrapie strains (ME7 and 139A), in different mouse strains (C57BL/6J and Compton White), and at several dilutions of the scrapie inoculum.