Selective removal of sulphur protecting groups of cysteine residues by sulphenyl halides
- 1 January 1975
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications
- No. 24,p. 976-977
- https://doi.org/10.1039/c39750000976
Abstract
Sulphur protecting groups of cysteine, such as triphenylmethyl, diphenylmethyl, 4,4′-dimethoxydiphenylmethyl and acetamidomethyl groups, are cleanly removed by the action of 2-nitrophenylsulphenyl chloride in acetic acid and subsequent reduction of the S-(2-nitrophenylsulphenyl)cysteine residues formed to regenerate the thiol function.Keywords
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