PHASE-II TRIAL OF 5-FLUOROURACIL, ADRIAMYCIN, AND MITOMYCIN-C IN ADVANCED COLORECTAL CANCER

  • 1 January 1978
    • journal article
    • research article
    • Vol. 62  (4) , 563-565
Abstract
Thirty-five patients with advanced measurable colorectal cancer were treated with a combination of 5-fluorouracil (5-FU), adriamycin and mitomycin C (FAM). Objective regression of tumor was observed in 6 patients (17%); 7 patients (20%) demonstrated stabilization of disease. The FAM regimen was well tolerated with toxic effects limited to bone marrow depression and mild-to-moderate nausea and vomiting. FAM combination chemotherapy did not significantly improve survival in responding patients, nor was it more effective than 5-FU alone in achieving objective regression of disease.